The laminin–keratin link shields the nucleus from mechanical deformation and signalling by Zanetta Kechagia, Pablo Sáez, Manuel Gómez-González, Brenda Canales, Srivatsava Viswanadha, Martín Zamarbide, Ion Andreu, Thijs Koorman, Amy E. M. Beedle, Alberto Elosegui-Artola, Patrick W. B. Derksen, Xavier Trepat, Marino Arroyo, Pere Roca-Cusachs
Nature Materials volume 22, pages1409–1420 (2023). The cell skeleton (cytoskeleton) is formed by multiple filaments of different mechanical properties, creating a dense mesh with diverse and complex responses. These cytoskeleton networks interact with the extracellular matrix (ECM) to determine the cell behavior. The paper by Kechagia et al. shows that laminin, a ubiquitous protein in […]
